Immunogen sequence: MATVTKAPKK QIQFADDMQE FTKFPTKTGR RSLSRSISQS STDSYSSAAS YTDSSDDEVS PREKQQTNSK GSSNFCVKNI KQAEFGRREI EIAEQDMSAL ISLRKRAQGE KPLAGAKIVG CTHITAQTAV LIETLCALGA QCRWSACNIY STQNEVAAAL AEAGVAVFAW KGESEDDFWW CIDRCVNMDG WQANMILDDG GDLTHWVYKK YPNVFKKIRG IVEESVTGVH; Positive Samples: 293T, U-251MG, SKOV3, Mouse brain, Rat spinal cord; Cellular Location: Apical cell membrane, Cytoplasm, Endoplasmic reticulum, Microsome, cytosol
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
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Protein Aliases: adenosylhomocysteinase-like 1; AdoHcyase 2; DC-expressed AHCY-like molecule; dendritic cell expressed AHCY-like protein; inositol 1,4,5-trisphosphate receptor-binding protein; IP(3)Rs binding protein released with IP(3); IP3R binding protein released with inositol 1,4,5-trisphosphate; IP3R-binding protein released with inositol 1,4,5-trisphosphate; IRBIT; protein phosphatase 1, regulatory subunit 78; Putative adenosylhomocysteinase 2; S-adenosyl homocysteine hydrolase homolog; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase, related sequence 3; S-adenosylhomocysteine hydrolase-like 1; S-adenosylhomocysteine hydrolase-like protein 1
Gene Aliases: 1110034F20Rik; AA409031; AA414901; Ahcy-rs3; AHCYL1; DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA
Molecular Function: hydrolase