Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and in the maintenance of cardiovascular functioning. In hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions. ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and can exert central effects such as decreasing food ingestion.
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Protein Aliases: Adrenomedullin; AM; AMpreproadrenomedullin; PAMP; preproadrenomedullin; Pro-adrenomedullin; Proadrenomedullin N-20 terminal peptide; ProAM N-terminal 20 peptide; ProAM-N20
Gene Aliases: ADM; AM; PAMP
UniProt ID: (Human) P35318
Entrez Gene ID: (Human) 133