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The Argonaute family of proteins play roles in RNA interference and in short-interfering-RNA-mediated gene silencing. Small interfering RNAs (siRNAs) have gained much attention for their powerful ability to suppress gene expression. Introduction of double-stranded RNA (dsRNA), that are homologues in sequence to a gene, has proven to suppress that gene's expression through a process known as RNA interference (RNAi); this process post-transcriptionally silences a gene through mRNA inhibition or degradation. Both biochemical and genetic studies have led to the identification of two, conserved gene families that are universal components of the interference process. These are the Dicer family, which is comprised of members of the Ribonuclease III family of enzymes, and the Argonaute gene family. Argonaute proteins addition to their role in RNAi process, may also influence development, such as, stem cell fate determination.
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Protein Aliases: argonaute 1; argonaute 2; argonaute 3; Argonaute RISC catalytic component 1; Argonaute RISC catalytic component 2; Argonaute RISC catalytic component 3; Argonaute1; Argonaute2; Argonaute3; CTA-204B4.6; eIF-2C 1; eIF-2C 2; eIF-2C 3; eIF2C 1; eIF2C 2; Eukaryotic translation initiation factor 2C 1; Eukaryotic translation initiation factor 2C 2; Eukaryotic translation initiation factor 2C 3; eukaryotic translation initiation factor 2C, 1; eukaryotic translation initiation factor 2C, 2; eukaryotic translation initiation factor 2C, 3; Golgi Endoplasmic Reticulum protein 95 kDa; hAgo2; hAgo3; PAZ Piwi domain protein; PPD; Protein argonaute-1; Protein argonaute-2; Protein argonaute-3; Protein slicer; Putative RNA-binding protein Q99
Gene Aliases: AGO1; AGO2; AGO3; EIF2C; EIF2C1; EIF2C2; EIF2C3; GERP95; hAgo1; Q10; Q99
Molecular Function: translation initiation factor