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Synucleins (α, β, and γ) are a family of cytoplasmic proteins found predominantly, and abundantly, in the brain with cellular distribution concentrated in presynaptic nerve terminals, primarily near vesicles. Synucleins are thought to be involved in neuronal plasticity, synaptic function, and neurodegenerative disease. α-Synuclein (~18 kDa) is abundant in Lewy Bodies in sporadic Parkinson's Disease (PD) and Dementia with Lewy Bodies (DLB). It has been reported that the NAC fragment from α-synuclein is a major component of amyloid plaques in Alzheimer's Disease. LB509 reacts with α-synuclein but not SM-synuclein. Reactivity has not been observed with γ-synuclein. Positive tissue: Parkinson's disease tissue.
Expected Staining Pattern: Cytoplasmic
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
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Protein Aliases: Alpha synuclein; Alpha-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)
Gene Aliases: NACP; PARK1; PARK4; PD1; SNCA
UniProt ID: (Human) P37840
Entrez Gene ID: (Human) 6622
Molecular Function: membrane trafficking regulatory protein