|Tested species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues H(44) M N V Q N G K W E S D P S G T K T C(62) of mouse APP isoform A.|
|Storage buffer||whole serum|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-18318 detects APP from rat samples.
PA1-18318 has been successfully used in immunohistochemistry procedures.
The PA1-18318 immunogen is a synthetic peptide corresponding to residues H(44) M N V Q N G K W E S D P S G T K T C(62) of mouse APP isoform A, conjugated to Blue Carrier Protein.
Reconstitute with 100 ul of distilled water.
APP functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. The APP protein is involved in cell mobility and transcription regulation through protein-protein interactions. APP can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. APP couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.