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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human AR (2-53 aa).|
|Purification||Ammonium sulfate precipitation|
|Storage buffer||physiological saline|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Androgen receptor (AR) belongs to the super-family of nuclear hormone receptors that employ complex molecular mechanisms to guide the development and physiological functions of their target tissues. Androgen receptor function plays a pivotal role in normal prostate development and physiology as well as prostate tumorigenesis. Androgen stimulation results in cell proliferation in both developing prostate and the malignant prostate. The transcriptional activity of the AR is modulated by a large and growing number of interacting proteins that function as co-activators and co-repressors. Androgen Receptor a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
androgen nuclear receptor variant 2; androgen receptor splice variant 4b; DHTR; dihydrotestosterone receptor; NR3C4; nuclear receptor subfamily 3 group C member 4
AIS; AR; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM