Immunogen sequence: NLVNLCTKEV LLKGGKREEE KPFRDCADVY QAGFNKSGIY TIYINNMPEP KKVFCNMDVN GGGWTVIQHR EDGSLDFQRG WKEYKMGFGN PSGEYWLGNE FIFAITSQRQ YMLRIELMDW EGNRAYSQYD RFHIGNEKQN Y; Positive Samples: A549, mouse lung
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia.
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Protein Aliases: ANG-1; Angiopoietin-1
Gene Aliases: 1110046O21Rik; AGP1; AGPT; Agpt1; Ang-1; ANG1; ANGPT1; KIAA0003
Molecular Function: signaling molecule