PA5-27299 targets Angiopoietin 2 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-27299 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 308 of Human Angiopoietin 2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
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Protein Aliases: AGPT2; ANG-2; ANG2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; Tie2-ligand
Gene Aliases: AGPT2; ANG2; ANGPT2
UniProt ID: (Human) O15123
Entrez Gene ID: (Human) 285
Molecular Function: signaling molecule