|ELISA (ELISA)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||HMW conjugate Synthetic peptide corresponding to amino acids 40-49 of the angiotensinogen precursor (Swiss-Prot entry P01019).|
|Storage buffer||PBS, pH 7.2|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
This antibody does not react with angiotensin II, III, or angiotensinogen in ELISA.
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; FLJ92595; FLJ97926; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
Gene Aliases: AGT; ANHU; SERPINA8
UniProt ID: (Human) P01019
Entrez Gene ID: (Human) 183
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