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          • Primary Antibodies ›
          • Angiotensin I-VII Antibodies

          Invitrogen

          Angiotensin I-VII Monoclonal Antibody (A4)

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          Cite Angiotensin I-VII Monoclonal Antibody (A4)

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          • Antibody Testing Data (3)
          Angiotensin I-VII Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Angiotensin I-VII Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

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          Angiotensin I-VII Antibody (MA565967) in IHC (P)

          Immunohistochemistry analysis of Angiotensin I-VII in paraffin-embedded Human Liver cancer tissue. Samples were incubated with Angiotensin I-VII Monoclonal (Product # MA565967) antibody using a dilution of 40 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG (2 µg/mL) and DAB. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          Angiotensin I-VII Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Angiotensin I-VII Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Angiotensin I-VII Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Angiotensin I-VII Monoclonal Antibody (A4)

          Product Details

          MA565967

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.01-2 µg/mL
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          5-40 µg/mL
          -

          Immunocytochemistry (ICC/IF)

          5-20 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Rat

          Host/Isotype

          Mouse / IgG2a, lambda

          Class

          Monoclonal

          Type

          Antibody

          Clone

          A4

          Immunogen

          OVA Conjugated Angiotensin 1-7 (Ang1-7) (Asp34-Pro40)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          200 µg

          Purification

          Protein A/G

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.05% ProClin 300

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_3715115

          Target Information

          Angiotensin I through VII are bioactive peptides that form part of the reninangiotensin system (RAS), integral to regulating cardiovascular, renal, and fluid electrolytes. Angiotensin I, an inactive precursor, is converted into Angiotensin II, a potent vasoconstrictor, which in turn can be further processed into smaller peptides, such as Angiotensin III, IV, and Angiotensin(17). Angiotensin(17) is particularly noteworthy for its beneficial roles in countering the effects of Angiotensin II; it acts via the Mas receptor and is known for its protective effects against vascular aging. It reduces inflammation, oxidative stress, and modulates pathways related to prostaglandin, bradykinin, and nitric oxide. These peptides play diverse roles in maintaining blood pressure and hydroelectrolyte balance, alongside influencing cardiac and vascular functions. Research continues to elucidate the distinct physiological roles of each peptide, particularly the interplay between the traditional angiotensin pathways and the more recently understood actions mediated by angiotensin(17).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Bioinformatics

          Protein Aliases: ACE-related carboxypeptidase; ACE2; alpha-1 antiproteinase, antitrypsin; Angiotensin 1-7; angiotensin I; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; Angiotensin I-VII; angiotensin II; angiotensin-converting enzyme homolog; angiotensin-converting enzyme-related carboxypeptidase; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); anigotensin-converting enzyme-related carboxypeptidase; dipeptidyl carboxydipeptidases; ACE2; fetal-liver predominant transporter 1; metalloprotease MPROT15; peptidyl-dipeptidase A; pre-angiotensinogen; preangiotensinogen; renal angiotensin-converting enzyme 2; sACE2; N-terminally-truncated natural isoform; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; unnamed protein product; zinc metalloprotease

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          Gene Aliases: ACEH; Ang; AngII; ANHU; ANRT; hFLT1; PAT; SERPINA8

          View more View less

          UniProt ID: (Human) Q9BYF1, (Human) P01019, (Rat) Q5EGZ1, (Rat) P01015

          View more View less

          Entrez Gene ID: (Human) 59272, (Human) 183, (Rat) 302668, (Rat) 24179

          View more View less

          Function(s)
          virus receptor activity endopeptidase activity carboxypeptidase activity metallocarboxypeptidase activity protein binding metallopeptidase activity peptidyl-dipeptidase activity zinc ion binding identical protein binding transporter activator activity serine-type endopeptidase inhibitor activity hormone activity growth factor activity superoxide-generating NADPH oxidase activator activity sodium channel regulator activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding receptor agonist activity
          Process(es)
          ovarian follicle rupture blood vessel development branching involved in ureteric bud morphogenesis positive regulation of cytokine production kidney development regulation of systemic arterial blood pressure by circulatory renin-angiotensin angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin regulation of heart rate vasodilation by angiotensin involved in regulation of systemic arterial blood pressure regulation of blood vessel size by renin-angiotensin brain renin-angiotensin system renal system process angiotensin-mediated drinking behavior regulation of systemic arterial blood pressure by renin-angiotensin positive regulation of extracellular matrix constituent secretion protein import into nucleus cellular sodium ion homeostasis cell-matrix adhesion cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration female pregnancy establishment of blood-nerve barrier regulation of blood pressure positive regulation of cell proliferation negative regulation of cell proliferation associative learning response to cold response to mechanical stimulus response to salt stress regulation of gene expression positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression positive regulation of cardiac muscle cell apoptotic process positive regulation of norepinephrine secretion positive regulation of epithelial to mesenchymal transition positive regulation of macrophage derived foam cell differentiation positive regulation of neuron projection development artery smooth muscle contraction response to muscle activity involved in regulation of muscle adaptation negative regulation of angiogenesis vasopressin secretion extracellular matrix organization negative regulation of cell growth peristalsis response to estradiol positive regulation of superoxide anion generation positive regulation of peptidyl-serine phosphorylation negative regulation of tissue remodeling operant conditioning positive regulation of insulin secretion involved in cellular response to glucose stimulus aldosterone secretion angiotensin-activated signaling pathway positive regulation of multicellular organism growth vasoconstriction vasodilation hormone metabolic process drinking behavior regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of fatty acid biosynthetic process positive regulation of epidermal growth factor receptor signaling pathway positive regulation of blood pressure positive regulation of transcription, DNA-templated positive regulation of organ growth positive regulation of insulin receptor signaling pathway astrocyte activation fibroblast proliferation positive regulation of fibroblast proliferation regulation of long-term neuronal synaptic plasticity smooth muscle cell proliferation regulation of inflammatory response positive regulation of inflammatory response smooth muscle cell differentiation negative regulation of neurotrophin TRK receptor signaling pathway stress-activated MAPK cascade positive regulation of protein kinase B signaling regulation of calcium ion transport regulation of transmission of nerve impulse cell growth involved in cardiac muscle cell development ERK1 and ERK2 cascade uterine smooth muscle contraction cellular response to mechanical stimulus positive regulation of branching involved in ureteric bud morphogenesis positive regulation of cholesterol metabolic process positive regulation of protein kinase C activity regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly positive regulation of membrane hyperpolarization positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of gap junction assembly regulation of cardiac conduction cellular response to angiotensin positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration positive regulation of L-lysine import across plasma membrane positive regulation of L-arginine import across plasma membrane response to angiotensin positive regulation of reactive oxygen species metabolic process positive regulation of extrinsic apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter angiotensin maturation proteolysis tryptophan transport viral entry into host cell receptor-mediated virion attachment to host cell negative regulation of smooth muscle cell proliferation positive regulation of amino acid transport maternal process involved in female pregnancy positive regulation of cardiac muscle contraction negative regulation of ERK1 and ERK2 cascade amino acid import across plasma membrane entry receptor-mediated virion attachment to host cell positive regulation of L-proline import across plasma membrane regulation of cell growth blood vessel remodeling regulation of blood volume by renin-angiotensin G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway cell-cell signaling regulation of vasoconstriction low-density lipoprotein particle remodeling regulation of renal sodium excretion nitric oxide-cGMP-mediated signaling pathway regulation of cell proliferation negative regulation of sodium ion transmembrane transport regulation of cytokine production viral life cycle receptor-mediated endocytosis of virus by host cell membrane fusion regulation of blood vessel diameter
          It has to be done as per old AB suggested Products section.

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