Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
|Tested species reactivity||Dog , Mouse , Rabbit , Human , Rat|
|Published species reactivity||Porcine , Sheep , Human , Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||A synthetic peptide derived from the spectrin-binding domain of the human ankyrin G protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Ankyrin-G is found in several tissues including brain where, due to tissue-specific RNA processing, it is expressed as two different isoforms, localized to axon initial segments and nodes of Ranvier. Ankyrin-G is also found at sites of epithelial cell-cell contact and in the intracellular membranes of some cells. Ankyrin-G isoforms contain a unique stretch of sequence highly enriched in serine and threonine residues immediately following a globular head domain. Ankyrin-G is thought to participate in the maintenance and targeting of ion channels and cell adhesion molecules to the nodes of Ranvier and to axon initial segments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
33-8800 was used in immunohistochemistry and western blot to identify the role of SCN5A mutations in cardiac functions
|Park DS,Cerrone M,Morley G,Vasquez C,Fowler S,Liu N,Bernstein SA,Liu FY,Zhang J,Rogers CS,Priori SG,Chinitz LA,Fishman GI||The Journal of clinical investigation (125:403)||2015|
A human Dravet syndrome model from patient induced pluripotent stem cells.
33-8800 was used in immunohistochemistry to study a cellular model of Dravet syndrome
|Higurashi N,Uchida T,Lossin C,Misumi Y,Okada Y,Akamatsu W,Imaizumi Y,Zhang B,Nabeshima K,Mori MX,Katsurabayashi S,Shirasaka Y,Okano H,Hirose S||Molecular brain (6:null)||2013|
Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization.
33-8800 was used in immunohistochemistry to study the role of desmosomes and adherens junctions in gap junction formation by cx43
|Chkourko HS,Guerrero-Serna G,Lin X,Darwish N,Pohlmann JR,Cook KE,Martens JR,Rothenberg E,Musa H,Delmar M||Heart rhythm : the official journal of the Heart Rhythm Society (9:1133)||2012|
Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system.
||Çolakoğlu G,Bergstrom-Tyrberg U,Berglund EO,Ranscht B||Proceedings of the National Academy of Sciences of the United States of America (111:E394)||2014|
Essential role of oligodendrocytes in the formation and maintenance of central nervous system nodal regions.
||Mathis C,Denisenko-Nehrbass N,Girault JA,Borrelli E||Development (Cambridge, England) (128:4881)||2001|
Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia.
||Edgar JM,McLaughlin M,Yool D,Zhang SC,Fowler JH,Montague P,Barrie JA,McCulloch MC,Duncan ID,Garbern J,Nave KA,Griffiths IR||The Journal of cell biology (166:121)||2004|
AI314020, ANKYRIN-G, Ankyrin-3, 2900054D09Rik, RP11-369L1.1, Ankyrin-G, Ank-3, AnkG
ankyrin-3, brain-specific ankyrin-G, ankyrin G119, Ankyrin-3, ANK-3