Recommended positive controls: A549, HeLa, HCT116, human ANXA2-transfected 293T.
Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Pig (100%), Sheep (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; epididymis secretory protein Li 270; Lipocortin II; p36; PAP-IV; Placental anticoagulant protein IV; Protein I
Gene Aliases: ANX2; ANX2L4; ANXA2; CAL1H; HEL-S-270; LIP2; LPC2; LPC2D; P36; PAP-IV
UniProt ID: (Human) P07355
Entrez Gene ID: (Human) 302
Molecular Function: calcium-binding protein