Immunogen sequence: IEILASRTPE EIRRISQTYQ QQYGRSLEDD IRSDTSFMFQ RVLVSLSAGG RDEGNYLDDA LVRQDAQDLY EAGEKKWGTD EVKFLTVLCS RNRNHLLHVF DEYKRISQKD IEQSIKSETS GSFEDALLAI VKCMRNKSAY FAEKLYKSMK GLGTDDNTLI RVMVSRAEID MLDIRAHFKR LYGKSLYSFI KGDTSGDYRK VLLVLCGGDD; Positive Samples: BxPC-3, MCF7, A-549, SW620, HepG2, Mouse liver, Mouse kidney, Mouse lung, Rat kidney
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.
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Protein Aliases: 35-beta calcimedin; 36 kDa zymogen granule membrane-associated protein; Annexin A4; Annexin IV; annexin IV (placental anticoagulant protein II); Annexin-4; ANXA 4; Carbohydrate-binding protein p33/p41; Chromobindin-4; Endonexin I; epididymis secretory protein Li 274; Lipocortin IV; P32.5; PAP-II; Placental anticoagulant protein II; PP4-X; proliferation-inducing gene 28; proliferation-inducing protein 28; Protein II; ZAP 36/annexin IV; ZAP36
Gene Aliases: AI265406; AIV; ANX4; ANXA4; AW106930; HEL-S-274; P32.5; PAP-II; PIG28; PP4-X; Xanx-4; ZAP36
Molecular Function: calcium-binding protein