Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described.
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Protein Aliases: 67 kDa calelectrin; Annexin 6; Annexin A6; Annexin VI; annexin VI (p68); annexin VI, p68; Annexin-6; ANX6; ANXA6; calcium-binding protein 65/67; calcium-binding protein CATA 65/67; calcium-binding protein p68; calelectrin; Calphobindin II; Calphobindin-II; CBP 65/67; CBP68; Chromobindin 20; Chromobindin-20; CPB II; CPB-II; Lipocortin VI; p68; p70; Protein III; testis secretory sperm-binding protein Li 198a
Gene Aliases: ANX6; ANXA6; AnxVI; AW107198; Cabm; Camb; CBP68; CPB-II