Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
Apolipoprotein A-1, also known as APOA1, is a human protein with a specific role in lipid metabolism. It binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. The gene is mapped to 11q23. And it is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence. The ApoA-I protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I is also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Additionally, ApoA-I overexpression promotes macrophage-specific reverse cholesterol transport.
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Protein Aliases: Apo-AI; ApoA-I; Apoa1; Apolipoprotein A-I; Apolipoprotein A1; ProapoA-I; Proapolipoprotein A-I; Truncated apolipoprotein A-I
Gene Aliases: Alp-1; apo-AI; Apoa-1; apoA-I; Apoa1; Brp-14; Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2
UniProt ID: (Mouse) Q00623
Entrez Gene ID: (Mouse) 11806