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Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
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Protein Aliases: Apo-CIII; apoC-III; Apolipoprotein; apolipoprotein C-3; Apolipoprotein C-III; Apolipoprotein C3; MGC150353
Gene Aliases: apo-CIII; ApoC-III; APOC3; APOCIII; HALP2
UniProt ID: (Human) P02656
Molecular Function: apolipoprotein