Positive Control: Human liver tissue, HepG2.
Subcellular Location: Secreted.
Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
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Protein Aliases: Apo-CIII; apoC-III; Apolipoprotein; Apolipoprotein C-III; Apolipoprotein C3; MGC150353
Gene Aliases: APOC3; APOCIII; HALP2
UniProt ID: (Human) P02656
Entrez Gene ID: (Human) 345
Molecular Function: apolipoprotein