Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-70415
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1.0 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
synthetic peptide directed towards the middle region of human Argonaut 3 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5-1.0 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 2% sucrose |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2689682 |
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
AGO3 (protein argonaute-3) is required to RNA-mediated gene silencing (RNAi). It binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. AGO3 is proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: argonaute 3; Argonaute RISC catalytic component 3; Argonaute3; eIF-2C 3; eIF2C 3; Eukaryotic translation initiation factor 2C 3; eukaryotic translation initiation factor 2C, 3; mAgo3; Piwi/Argonaute family protein meIF2C3; Protein argonaute-3
Gene Aliases: Ago3; AW048688; C130014L07Rik; Eif2c3
UniProt ID: (Mouse) Q8CJF9
Entrez Gene ID: (Mouse) 214150
Molecular Function:
translation initiation factor
mRNA catabolic process
regulation of translation
RNA secondary structure unwinding
gene silencing by RNA
pre-miRNA processing
production of miRNAs involved in gene silencing by miRNA
miRNA mediated inhibition of translation
miRNA loading onto RISC involved in gene silencing by miRNA
regulation of stem cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support