PA5-28372 targets ARSA in WB applications and shows reactivity with Human samples.
The PA5-28372 immunogen is recombinant fragment corresponding to a region within amino acids 169 and 405 of Human ARSA.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Multiple alternatively spliced transcript variants, one of which encodes a distinct protein, have been described for this gene.
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Protein Aliases: Arylsulfatase A; Arylsulfatase A component B; Arylsulfatase A component C; ASA; Cerebroside-sulfatase; MLD
Gene Aliases: ARSA; MLD
UniProt ID: (Human) P15289
Entrez Gene ID: (Human) 410
Molecular Function: hydrolase