PA5-27794 targets ARSB in WB applications and shows reactivity with Human samples.
The PA5-27794 immunogen is recombinant fragment corresponding to a region within amino acids 250 and 529 of Human ARSB.
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Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Protein Aliases: Arylsulfatase B; ASB; G4S; MPS6; N-acetylgalactosamine-4-sulfatase
Gene Aliases: ARSB; ASB; G4S; MPS6
UniProt ID: (Human) P15848
Entrez Gene ID: (Human) 411
Molecular Function: hydrolase