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Sulfatases, such as ARSG, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This gene, a novel arylsulfatase, has activity toward pseudosubstrates including p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. Activity is competitively inhibited by phosphate. The unprocessed protein is active as a 63-kDa monomer and demonstrates an acidic pH optimum as typically seen for lysosomal sulfatases. The protein accumulates within lysosomes and is also a glycoprotein that binds specifically to mannose 6-phosphate receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Arylsulfatase G; ASG
Gene Aliases: 6330406P08Rik; AI846872; ARSG; KIAA1001; RGD1306571; UNQ839/PRO1777
UniProt ID: (Human) Q96EG1, (Rat) Q32KJ9, (Mouse) Q3TYD4
Entrez Gene ID: (Human) 22901, (Rat) 303631, (Mouse) 74008
Molecular Function:
hydrolase
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