This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
A suggested positive control for this product is A431 cells.
Aurora protein kinase family (consisting of Aurora-A,-B and-C) is an important group of enzymes that controls several aspects of cell division in mammalian cells. In humans, Aurora-A is localized to the centrosome in prophase, subsequently spreading to the mitotic spindles/centrosomes. Aurora-B is found at the kinetochore, mainly at the midzone, during anaphase. Aurora-C is localized to the centrosomes from anaphase to cytokinesis. Aurora B is the catalytic component of the chromosomal passenger complex, which is composed of three additional noncatalytic subunits that direct its activity: survivin, INCEP, and borealin. Aurora B appears to be required for several mitotic processes, including aberrant chromosome alignment/segregation and cytokinesis. Phosphorylation of Histone H3 (Ser10 and Ser28) by Aurora B contributes to chromosome number instability and mitotic chromosome condensation.
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Protein Aliases: AIK2; AIM-1; AIM1; ARK-2; ARK2; AURKB; Aurora 1; aurora B; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1-related kinase 2; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; STK-1; STK12; STK5
Gene Aliases: AIK2; AIM-1; AIM1; AIRK2; AL022959; ARK-2; ARK2; AurB; AURKB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK1; STK12; STK5