Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-103185
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human AurB/C, corresponding to a region within N-terminal amino acids. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2852553 |
Target Information
Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: AIM-1; ARK-2; ARK-3; Aurora 1; Aurora 3; aurora B; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora kinase C; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; aurora-related kinase 3; Aurora/IPL1-related kinase 2; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 1; Aurora/IPL1/Eg2 protein 2; epididymis secretory protein Li 90; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine kinase 13 (aurora/IPL-like); serine/threonine kinase 13 (aurora/IPL1-like); serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase aurora-C; STK-1
Gene Aliases: AIE1; AIE2; AIK2; AIK3; AIM-1; AIM1; AIRK2; AIRK3; AL022959; ARK-2; ARK-3; ARK2; ARK3; AurB; AurC; AURKB; aurkb-sv1; aurkb-sv2; AURKC; aurora-C; HEL-S-90; IAK3; IPL1; PPP1R48; SPGF5; STK-1; STK1; STK12; STK13; STK5
UniProt ID: (Human) Q96GD4, (Human) Q9UQB9, (Mouse) O70126, (Rat) O55099, (Mouse) O88445
Entrez Gene ID: (Human) 9212, (Human) 6795, (Mouse) 20877, (Rat) 114592, (Mouse) 20871, (Rat) 292554
Molecular Function:
non-receptor serine/threonine protein kinase
negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
protein phosphorylation
spindle organization
sister chromatid cohesion
aging
cell proliferation
attachment of spindle microtubules to kinetochore
abscission
histone modification
protein sumoylation
anaphase-promoting complex-dependent catabolic process
spindle checkpoint
negative regulation of protein binding
positive regulation of telomere maintenance via telomerase
negative regulation of cytokinesis
positive regulation of cytokinesis
protein localization to kinetochore
cellular response to UV
cleavage furrow formation
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
histone H3-S28 phosphorylation
protein autophosphorylation
mitotic spindle midzone assembly
positive regulation of telomerase activity
regulation of chromosome segregation
regulation of signal transduction by p53 class mediator
positive regulation of telomere capping
cytokinesis
spermatogenesis
histone-serine phosphorylation
oocyte development
meiotic cell cycle
cell cycle
mitotic spindle organization
mitotic nuclear division
phosphorylation
regulation of cytokinesis
cell division
regulation of signal transduction
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
histone serine kinase activity
metal ion binding
protein kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support