This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with Monkey, Horse, Sheep.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
AXL is a member of the AXL/UFO subfamily of receptor tyrosine kinases that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6. This binding leads to regulation of many physiological processes including cell survival, proliferation, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by the ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2, and PIK3R3. Other downstream substrate candidates for AXL include CBL, NCK2, SOCS1, and TNS2. AXL also plays a role in the inhibition of toll-like receptors (TLRs)-mediated innate immune response. AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, myeloproliferative disorders, prostatic carcinoma cells, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AXL oncogene; AXL transforming sequence/gene; Tyrosine-protein kinase receptor UFO; UFO
Gene Aliases: ARK; AXL; JTK11; Tyro7; UFO
UniProt ID: (Human) P30530
Entrez Gene ID: (Human) 558