Positive Control: SH-SY-5Y, HepG2, SH-SY-5Y, SK-Br-3, rat uterus tissue, human gallbladder tissue, human lung cancer tissue, human colon tissue.
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BAF57; BRG1-associated factor 57; chromatin remodeling complex BRG1-associated factor 57; SMARCE 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Gene Aliases: BAF57; CSS5; SMARCE1
UniProt ID: (Human) Q969G3
Entrez Gene ID: (Human) 6605
Molecular Function: chromatin/chromatin-binding, or -regulatory protein