The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 or Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
The Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers. Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and bladder. BCAS3 is thought to be an estrogen receptor (ER)-alpha co-activator that acts through PELP1, another ER-alpha that in turn activates BCAS3 expression. This may set up a positive feedback loop leading to ER-a signal amplification in the cell which may play a significant role in breast cancer. BCAS3 expression has also been observed in embryonic stem cells and vascular precursors, suggesting that it may also play a role in embryogenesis and tumor angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BCAS3; BCAS4/BCAS3 fusion; breast carcinoma amplified sequence 3; breast carcinoma amplified sequence 4/3 fusion protein; Breast carcinoma-amplified sequence 3; GAOB1; Maab1 protein; metastasis associated antigen of breast cancer; protein Maab1; Rudhira
Gene Aliases: BCAS3; GAOB1; MAAB
UniProt ID: (Human) Q9H6U6
Entrez Gene ID: (Human) 54828