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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant, full length, human Bcl10 protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay dependent|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-20160 detects Bcl10 in human samples.
MA1-20160 has been successfully used in ELISA, immunohistochemistry (paraffin) and Western blot procedures.
The MA1-20160 immunogen is recombinant, full length, human Bcl10 protein.
Bcl 10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (Caspase Recruitment Domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl 10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl 10 cellular overexpression induces JNK, p38, and NF-kappaB activation. Deregulation of Bcl 10 expression was also demonstrated to be involved in cellular oncogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bcl-10CED-3/ICH-1 prodomain homologous E10-like regulator; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular ho; cellular homolog of vCARMEN; cellular-E10; CIPER; hCLAP; mammalian CARD-containing adapter molecule E10
BCL10; c-E10; CARMEN; CIPER; CLAP; IMD37; mE10