|Tested species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human BCL-10 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/200 - 1/400|
|Immunofluorescence (IF)||1/200 - 1/1000|
|Immunohistochemistry (IHC)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-14756 targets BCL-10 in FACS, IF, IHC, and WB applications and shows reactivity with Human and mouse samples.
The MA5-14756 immunogen is purified recombinant fragment of human BCL-10 expressed in E. Coli.
MA5-14756 detects BCL-10 which has a predicted molecular weight of approximately 26kDa.
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue lymphoma. The protein encoded by this gene contains a caspase recruitment domain , and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.