|Tested species reactivity||Bovine, Human, Mouse, Sheep, Pig, Rabbit, Rat|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant protein corresponding to amino acids 3-484 of the human Bcl-6 protein|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||3-5 µg/10^6 cells|
|Immunohistochemistry (Paraffin) (IHC (P))||1:20|
|Western Blot (WB)||1:10-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11493 targets BCL-6 in IHC (P) and Western blot applications and shows reactivity with Bovine, Human, Ovine, Porcine, Rabbit, Mouse and Rat samples.
The MA5-11493 immunogen is recombinant protein corresponding to amino acids 3-484 of the human Bcl-6 protein.
Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The expression of IgM is helpful in the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma.
MA5-11493 was used in immunohistochemistry to investigate the effect of IgM expressoin on the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma
|Demirkesen C,Tüzüner N,Esen T,Lebe B,Ozkal S||Leukemia research (35:1269)||2011|
E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response.
MA5-11493 was used in immunohistochemistry to investigate the correlation between miR-223 expression and gastric MALT lymphoma
|Liu TY,Chen SU,Kuo SH,Cheng AL,Lin CW||Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (23:1507)||2010|
B-cell lymphofollicular infiltrates in mycosis fungoides.
MA5-11493 was used in immunohistochemistry to investigate specific histopathological features of B-cell lymphofollicular infiltrates in mycosis fungoides
|Ferrara G,Chiarelli C,Simonetti S||Tumori (96:487)||2010|
Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity.
MA5-11493 was used in immunohistochemistry to investigate the role of Noxa expression in the pathogenesis of chronic lymphocytic leukemia
|Smit LA,Hallaert DY,Spijker R,de Goeij B,Jaspers A,Kater AP,van Oers MH,van Noesel CJ,Eldering E||Blood (109:1660)||2007|
Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease.
MA5-11493 was used in immunohistochemistry to examine the diagnostic and prognostic significance of multiple proteins in immunoproliferative small intestinal disease
|Vaiphei K,Kumari N,Sinha SK,Dutta U,Nagi B,Joshi K,Singh K||World journal of gastroenterology (12:3602)||2006|
Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction.
MA5-11493 was used in immunohistochemistry to study the changes in germinal center after the Epstein-Barr virus infection
|Kurth J,Hansmann ML,Rajewsky K,Küppers R||Proceedings of the National Academy of Sciences of the United States of America (100:4730)||2003|
Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma.
MA5-11493 was used in immunohistochemistry to investigate the occurrence of BCL6 mutation in different types of Hodgkin lymphoma
|Wlodarska I,Nooyen P,Maes B,Martin-Subero JI,Siebert R,Pauwels P,De Wolf-Peeters C,Hagemeijer A||Blood (101:706)||2003|
Enhancement of clonogenicity of human multiple myeloma by dendritic cells.
MA5-11493 was used in immunocytochemistry to investigate the interaction between tumors and dendritic cells
|Kukreja A,Hutchinson A,Dhodapkar K,Mazumder A,Vesole D,Angitapalli R,Jagannath S,Dhodapkar MV||The Journal of experimental medicine (203:1859)||2006|