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|Tested species reactivity||Human, Mouse, Pig, Rat|
|Published species reactivity||Rat, Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||A synthetic peptide, aa 3-14 (Cys-QSNRELVVDFLS) of human Bcl-X protein. This amino acid sequence is shared by human and murine bcl-X protein.|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-14008 targets BCL-X in FACS, IF, and IHC (P) applications and shows reactivity with Human, mouse, Porcine, and Rat samples.
The MA5-14008 immunogen is a synthetic peptide, aa 3-14 (Cys-QSNRELVVDFLS) of human Bcl-X protein. This amino acid sequence is shared by human and mouse bcl-X protein.
Bcl-X has two isoforms, Bcl-XL (long) a 241 amino acid protein and Bcl-XS (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl-2 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells.
MA5-14008 was used in western blot to examine the anti-apoptotic role of Bcl-xL and myeloid cell leukaemia-1 in colorectal cancer cells
|Schulze-Bergkamen H,Ehrenberg R,Hickmann L,Vick B,Urbanik T,Schimanski CC,Berger MR,Schad A,Weber A,Heeger S,Galle PR,Moehler M||World journal of gastroenterology (14:3829)||2008|
Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria.
MA5-14008 was used in western blot to study the role of Bcl-2 and mitochrondria in the neuroprotective effects of minocycline
|Wang J,Wei Q,Wang CY,Hill WD,Hess DC,Dong Z||The Journal of biological chemistry (279:19948)||2004|
Identification of rare Epstein-Barr virus infected memory B cells and plasma cells in non-monomorphic post-transplant lymphoproliferative disorders and the signature of viral signaling.
MA5-14008 was used in immunohistochemistry to investigate the role of Epstein-Barr virus infection in the immune response of non-monomorphic post-transplant lymphoproliferative disorders
|Shaknovich R,Basso K,Bhagat G,Mansukhani M,Hatzivassiliou G,Murty VV,Buettner M,Niedobitek G,Alobeid B,Cattoretti G||Haematologica (91:1313)||2006|
Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3.
MA5-14008 was used in immunohistochemistry to investigate cell death in osteoarthritic cartilage and the role of caspase-3 during this process
|Sharif M,Whitehouse A,Sharman P,Perry M,Adams M||Arthritis and rheumatism (50:507)||2004|
anti-apoptosis regulatory protein; anti-apoptotic Bcl-xL; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; bcl-2-like protein 1; bcl2-L-1; BCL2-like 1; protein phosphatase 1, regulatory subunit 52
Bcl(X)L; Bcl-X; Bcl-XL; BCL-XL/S; bcl2-L-1; BCL2L; BCL2L1; BCLX; BLC2L; PPP1R52