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Invitrogen
BCL2L12 Recombinant Rabbit Monoclonal Antibody (ARC2334)
FIGURE: 1 / 3
BCL2L12 Antibody (MA5-38012) in IHC (P)
Immunohistochemistry analysis of BCL2L12 in paraffin-embedded human esophageal cancer. Samples were incubated with BCL2L12 Monoclonal antibody (Product # MA5-38012) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-38012
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC2334
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human BCL2L12 (Q9HB09)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897930
Product Specific Information
Positive Samples: MCF7, PC-3
Immunogen sequence: GPPSTEKEAI LRRLVALLEE EAEVINQKLA SDPALRSKLV RLSSDSFARL VELFCSRDDS SRPSRACPGP PPPSPEPLAR LALAMELSRR VAGLGGTLAG L
Target Information
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bcl-2 related proline-rich protein; Bcl-2-like protein 12; Bcl-2-related proline-rich protein; Bcl2-L-12; BCL2-like 12 (proline rich)
Gene Aliases: BCL2L12; BPR
UniProt ID: (Human) Q9HB09
Entrez Gene ID: (Human) 83596
apoptotic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cellular senescence
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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