This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL and apos;s transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3; basic helix-loop-helix domain containing; basic helix-loop-helix domain containing, class B, 3; basic helix-loop-helix family, member e41; BHLHB3; bHLHe41; class B; Class B basic helix-loop-helix protein 3; Class E basic helix-loop-helix protein 41; DEC2; differentially expressed in chondrocytes 2; Differentially expressed in chondrocytes protein 2; Enhancer-of-split and hairy-related protein 1; hDEC2; SHARP-1; SHARP1
Gene Aliases: BHLHB3; BHLHE41; DEC2; hDEC2; SHARP1
UniProt ID: (Human) Q9C0J9
Entrez Gene ID: (Human) 79365