Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
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Protein Aliases: ARNT-like protein 1, brain and muscle; ARNTL; aryl hydrocarbon receptor nuclear translocator-like; Aryl hydrocarbon receptor nuclear translocator-like protein 1; basic-helix-loop-helix-PAS orphan MOP3; Basic-helix-loop-helix-PAS protein MOP3; bHLH-PAS protein JAP3; bHLHe5; BMAL1c; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; JAP3; Member of PAS protein 3; member of PAS superfamily 3; MGC47515; PAS domain-containing protein 3; PASD3; testis tissue sperm-binding protein Li 50e; TIC
Gene Aliases: ARNTL; BHLHE5; BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC
UniProt ID: (Human) O00327
Entrez Gene ID: (Human) 406