|Immunohistochemistry (Paraffin) (IHC (P))||2.5-5.0 µg/ml|
|Western Blot (WB)||2.5-5.0 µg/ml|
|Tested Species reactivity||Hamster, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide from the N-terminus of human Bak protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
PA5-16470 targets Bak in IHC (P) and WB applications and shows reactivity with mouse, Hamster, and Human samples.
The PA5-16470 immunogen is a synthetic peptide from the N-terminus of human Bak protein.
Bak or Bcl-2-homologous antagonist is a member of the Bcl-2 family of holologous proteins which function in the regulation of apoptosis. The Bcl-2 related proteins interact with one another through the formation of homo- and heterodimers. The susceptibility of cells to apoptotic stimuli is thought to be controlled by the relative ratios of the different Bcl-2 family proteins. Bak is a 211 aa protein which has been demonstrated to accelerate the rate of apoptosis in growth factor deprived murine lymphoid, neuronal and fibroblastic cell lines. Bak has been localized by immunohistochemistry to the cytosol of cells and stains in a punctate pattern characteristic of other bcl-2 family proteins, which have been localized to intracellular organelles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Apoptosis regulator BAK; Bcl-2 homologous antagonist/killer; Bcl-2-like protein 7; Bcl-2-likeous antagonist/killer; Bcl2 homologous antagonist/killer; BCL2-antagonist/killer 1; Bcl2-L-7; BCL2-like 7 protein; pro-apoptotic protein BAK
Gene Aliases: BAK; BAK-LIKE; BAK1; BCL2L7; CDN1; N-Bak; N-BAK1
Molecular Function: signaling molecule
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