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|Tested species reactivity||Mouse, Rat|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Synthetic peptide corresponding to a sequence at the amino terminal of the murine Bcl-2 protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Members of the Bcl-2 Family (including Bcl-2, Bcl-XLand Bax) play an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, Bax is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of Bax and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Mouse||Not Cited||Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells.||Zhu Y,Swanson BJ,Wang M,Hildeman DA,Schaefer BC,Liu X,Suzuki H,Mihara K,Kappler J,Marrack P||Proceedings of the National Academy of Sciences of the United States of America (101:7681)||2004|
|Human||1:1000||Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane.||Kaufmann T,Schlipf S,Sanz J,Neubert K,Stein R,Borner C||The Journal of cell biology (160:53)||2003|
||Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane.||Kaufmann T,Schlipf S,Sanz J,Neubert K,Stein R,Borner C||The Journal of cell biology (160:53)||2003|
Apoptosis regulator Bcl-2; B cell lymphoma 2 associated oncogene; B-cell leukemia/lymphoma 2; Bcl2-like protein; PPP1R50; protein phosphatase 1 regulatory subunit 50
AW986256; Bcl-2; Bcl2; C430015F12Rik; D630044D05Rik; D830018M01Rik