The interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer.
Tan L,Qu W,Wu D,Liu M,Ai Q,Hu H,Wang Q,Chen W,Zhou H
MA1-12246 was used in Western Blotting to suggest that IRF6 may enhance chemotherapeutic sensitivity of cisplatin mediated by affecting cell proliferation, migration and invasion along with apoptosis through regulating E-cadherin and Ki67, while the identified molecular mechanisms remain to be further explored.
Fri Apr 01 00:00:00 EDT 2022
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret C,Miah SMS,Rota G,Fonta NP,Wang H,Held W,Birchmeier W,Sexl V,Yang W,Vivier E,Ho PC,Brossay L,Guarda G
MA1-12246 was used in Flow cytometry/Cell sorting to investigate phosphatase Shp-2 exact role in NK cells.
Fri Mar 29 00:00:00 EDT 2019
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC
MA1-12246 was used in Flow Cytometry to study the mechanism of IL-15 function in autophagy and natural killer cell survival.
Wed Jul 18 00:00:00 EDT 2018
Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
Xu H,Zhu G,Tian Y
MA1-12246 was used in western blot to study the effect of trimetazidine on the survival of bone marrow mesenchymal stem cells in a model of hypoxia and following transplantation into rat heart
Wed Feb 01 00:00:00 EST 2012
Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.
Baquedano E,García-Cáceres C,Diz-Chaves Y,Lagunas N,Calmarza-Font I,Azcoitia I,Garcia-Segura LM,Argente J,Chowen JA,Frago LM
MA1-12246 was used in western blot to study the long-term effects of sub-chronic prenatal stress on cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats
Tue Apr 10 00:00:00 EDT 2012
MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3.
The Journal of cell biology
Hirai H,Verma M,Watanabe S,Tastad C,Asakura Y,Asakura A
MA1-12246 was used in western blot to study the mechanism by which the MyoD regulates myoblast apoptosis
Mon Oct 18 00:00:00 EDT 2010
Growth hormone-releasing peptide 6 protection of hypothalamic neurons from glutamate excitotoxicity is caspase independent and not mediated by insulin-like growth factor I.
The European journal of neuroscience
Delgado-Rubín A,Chowen JA,Argente J,Frago LM
MA1-12246 was used in western blot to study the mechanism by which growth hormone-releasing peptide-6 protects a hypothalamic neuronal cell line against monosodium glutamate-induced apoptosis
Mon Jun 01 00:00:00 EDT 2009
Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats.
Behavioural brain research
Nahas Z,Jiang Y,Zeidan YH,Bielawska A,Szulc Z,Devane L,Kalivas P,Hannun YA
MA1-12246 was used in western blot to study the relationship between hippocampal apopotosis and learned helplessness in vivo using an anti-ceramidase compound
Fri Jan 30 00:00:00 EST 2009
TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest.
Schneider L,Essmann F,Kletke A,Rio P,Hanenberg H,Schulze-Osthoff K,Nürnberg B,Piekorz RP
MA1-12246 was used in western blot to study the effects of TACC3 depletion on sensitivity to paclitaxel-induced cell death and p21WAF-mediated cell cycle arrest
Thu Jan 03 00:00:00 EST 2008
Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis.
Experimental cell research
Götschel F,Kern C,Lang S,Sparna T,Markmann C,Schwager J,McNelly S,von Weizsäcker F,Laufer S,Hecht A,Merfort I
MA1-12246 was used in western blot to elucidate whether glycogen synthase kinase-3 inhibition induces apoptosis in the presence of TNF-alpha in primary mouse hepatocytes
Tue Apr 01 00:00:00 EDT 2008
Bcl-2 protects against oxidative stress while inducing premature senescence.
Free radical biology & medicine
López-Diazguerrero NE,López-Araiza H,Conde-Perezprina JC,Bucio L,Cárdenas-Aguayo MC,Ventura JL,Covarrubias L,Gutiérrez-Ruíz MC,Zentella A,Königsberg M
MA1-12246 was used in western blot to study the role of Bcl-2 in protecting against oxidative stress while inducing premature senescence
Sat Apr 01 00:00:00 EST 2006
Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity.
Journal of neurochemistry
Delgado-Rubín de Célix A,Chowen JA,Argente J,Frago LM
MA1-12246 was used in western blot to study the role of growth hormone releasing peptide-6 as a survival factor in glutamate-induced excitotoxicity
Wed Nov 01 00:00:00 EST 2006
Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel.
Biochemical and biophysical research communications
Chai Y,Niu L,Sun XL,Ding JH,Hu G
MA1-12246 was used in immunocytochemistry to study the protection of PC12 cells against H2O2-induced oxidative injury by iptakalim-mediated opening of mitochondrial ATP-sensitive potassium channels
Fri Nov 17 00:00:00 EST 2006
Bcl-2 is a key factor for cardiac fibroblast resistance to programmed cell death.
The Journal of biological chemistry
Mayorga M,Bahi N,Ballester M,Comella JX,Sanchis D
MA1-12246 was used in western blot to study the role of Bcl-2 in heart fibroblast resistance to apoptosis
Fri Aug 13 00:00:00 EDT 2004
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane.
The Journal of cell biology
Kaufmann T,Schlipf S,Sanz J,Neubert K,Stein R,Borner C
MA1-12246 was used in immunocytochemistry and western blot to determine the signal characteristics that directs Bcl-x(L) and not Bcl-2 to the mitochondrial outer membrane
Mon Jan 06 00:00:00 EST 2003
Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches.
Journal of immunology (Baltimore, Md. : 1950)
Yamanaka T,Helgeland L,Farstad IN,Fukushima H,Midtvedt T,Brandtzaeg P
MA1-12246 was used in immunohistochemistry (frozen) to determine the spatial relationships of B cells, T cells, and dendritic cells in Peyer's patches during microbial colonization.
Wed Jan 15 00:00:00 EST 2003
Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice.
The Journal of cell biology
Putcha GV,Harris CA,Moulder KL,Easton RM,Thompson CB,Johnson EM
MA1-12246 was used in western blot to study the role of intrinsic and extrinsic signaling pathways in neuronal apoptosis
Mon Apr 29 00:00:00 EDT 2002