MA1-950 detects human and mouse Bcl-3 from transfected cells and shows no cross-reactivity to other Bcl isoforms.
MA1-950 has been successfully used in Western blot and FACS procedures. By Western blot, this antibody detects an ~47 kDa protein representing Bcl-3 from C57BI/6 human T cells and Bcl-3 transgenic ms T cells.
MA1-950 immunogen is full length Bcl-3 protein from mouse.
B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B-cell CLL/lymphoma 3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3 protein; B-cell lymphoma 3 protein homolog; B-cell lymphoma 3-encoded protein; BCL-3; Bcl-3 protein; chronic lymphatic leukemia protein; Proto-oncogene BCL3
Gene Aliases: AI528691; Bcl-3; BCL3; BCL4; D19S37