This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA5-15825 targets BECN1 in FACS, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15825 immunogen is purified recombinant fragment of human BECN1 expressed in E. Coli.
MA5-15825 detects BECN1 which has a predicted molecular weight of approximately 60kDa.
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATG6 autophagy related 6 homolog; ATG6, VPS30, beclin1, ATG6 autophagy related 6 homolog; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e
Gene Aliases: ATG6; beclin1; BECN1; GT197; VPS30
UniProt ID: (Human) Q14457
Entrez Gene ID: (Human) 8678