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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||16 amino acid peptide near the amino terminus of human Betatrophin|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A recommended positive control is rat liver tissue lysate.
At least three isoforms of Betatrophin are known to exist; this antibody will detect the two largest isoforms.
The Betatrophin protein, also known as the hepatocellular carcinoma-associated protein TD26, is an adipocyte- and liver-enriched insulin targeted gene that is thought to play a role in lipid metabolism be regulating serum triglyceride levels. Betatrophin is closely related to the angiopoietin-like (ANGPTL) protein family. Betatrophin mRNA increases in the cold environment and after treatment with a high-fat diet, while its mRNA levels decrease in response to fasting, suggesting that it may play a role in mediating thermogenesis and energy homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
angiopoietin-like 8; Angiopoietin-like protein 8; ANGPTL8; Betatrophin; betatrophin variant 1; betatrophin variant 2; hepatocellular carcinoma-associated gene TD26; hepatocellular carcinoma-associated protein TD26; hepatocellular carcinoma-associated protein TD26 homolog; Lipasin; PRO1185; PVPA599; Refeeding-induced fat and liver protein; RIFL; TD26; UNQ599/PRO1185
ANGPTL8; C19orf80; EG624219; Gm6484; PRO1185; PVPA599; RIFL; TD26; UNQ599/PRO1185