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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant full length protein (Human).|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-22009 detects Blooms Syndrome Protein in Human samples.
MA1-22009 has been successfully used in Immunohistochemistry (Frozen) and Western Blot procedures.
MA1-22009 immunogen corresponds to Recombinant full length protein (Human)..
The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. The BLM protein is a 1417 amino acid peptide with homology to the RecQ helicases, a subfamily of DExH box-containing DNA and RNA helicases. The BLM protein has similarity to 2 other proteins that are members of the subfamily, namely the gene product encoded by RECQL2, also called the Werner syndrome gene (WRN), and the product of the yeast gene SGS1. These proteins may interact with topoisomerases, have 42 to 44% amino acid identity across the conserved helicase motifs, are of similar length and contain highly negatively charged N-terminal regions and highly positively charged C-terminal regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BLM; Bloom syndrome, RecQ helicase-like; DNA helicase, RecQ-like type 2; recQ protein-like 3
BLM; BS; RECQ2; RECQL2; RECQL3