PA5-27384 targets BLM in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-27384 immunogen is recombinant fragment corresponding to a region within amino acids 1235 and 1417 of Human BLM.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bloom syndrome homolog; Bloom syndrome protein; Bloom syndrome protein homolog; Bloom syndrome, RecQ helicase-like; BS; DNA helicase, RecQ-like type 2; mBLM; RecQ helicase homolog; RecQ protein-like 3; RecQ-like type 2; RECQ2; RECQL2; RECQL3
Gene Aliases: BLM; BS; RECQ2; RECQL2; RECQL3