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Product Details
RP-43097
| Applications | Tested Dilution | Publications |
|---|---|---|
Control (Ctrl) |
Assay-dependent | - |
| Product Specifications | |
|---|---|
Species |
Bovine |
Expression System |
Bovine |
Molecular weight |
52.65 kDa |
Class |
Native |
Type |
Protein |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
3.7 mg/mL |
Purification |
purified |
Storage buffer |
50% water with 50% glycerol |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Product Specific Information
RP-43097 contains native bovine Activated Protein C protein.
RP-43097 may be used as a positive control in many immunological assays.
Target Information
Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 µg/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; EDQVDPRLIDGK; protein C prepropeptide
Entrez Gene ID: (Bovine) 281428
Molecular Function:
serine protease
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