PA1-825 detects C/EBP alpha protein in mouse samples.
PA1-825 has successfully been used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 30 and 43 kDa protein representing C/EBP alpha in mouse 3T3-L1 cells. These polypeptides are derived from alternative translation initiation.
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.
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Protein Aliases: C/EBP alpha; CCAAT/Enhancer Binding Protein Alpha; CCAAT/enhancer-binding protein alpha; CEBP
Gene Aliases: C/ebpalpha; CBF-A; Cebp; Cebpa
UniProt ID: (Mouse) P53566
Entrez Gene ID: (Mouse) 12606