PA1-825 detects C/EBP alpha protein in mouse samples.
PA1-825 has successfully been used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 30 and 43 kDa protein representing C/EBP alpha in mouse 3T3-L1 cells. These polypeptides are derived from alternative translation initiation.
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C EBP; C/EBP alpha; CCAAT/enhancer-binding protein alpha; OTTHUMP00000220269
Gene Aliases: C/ebpalpha; CBF-A; Cebp; Cebpa
UniProt ID: (Mouse) P53566
Entrez Gene ID: (Mouse) 12606