Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-ski; Proto-oncogene c-Ski; Ski oncogene; ski oncoprotein; ski sarcoma viral oncogene homolog; Sloan-Kettering viral oncogene homolog; v-ski avian sarcoma viral oncogene homolog
Gene Aliases: 2310012I02Rik; 2610001A11Rik; AA062172; AA589460; BC004088; c-ski; RGD1565591; SGS; SKI; SKV
UniProt ID: (Human) P12755
Entrez Gene ID: (Human) 6497, (Rat) 313757, (Mouse) 20481
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support