Peptide Sequence: MKPPAEDLSD ALCEFDAVLA DFASPFHERH FHYEEHLERM KRRSSASVSD SSGFSDSESA DSLYRNSFSF SDEKLNSPTD STPALLSATV TPQKAKLGDT KELEAFIADL DKTLASM
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression.
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Protein Aliases: bA157L14.2; Regulator of cell cycle RGCC; Response gene to complement 32 protein; RGC-32; RGC32
Gene Aliases: bA157L14.2; C13orf15; RGC-32; RGC32; RGCC
UniProt ID: (Human) Q9H4X1
Entrez Gene ID: (Human) 28984