C15orf23 is an essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. It promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.
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Protein Aliases: Kinastrin; Kinetochore-localized astrin-binding protein; kinetochore-localized astrin/SPAG5 binding protein; Kinetochore-localized astrin/SPAG5-binding protein; putative TRAF4-associated factor 1; SKAP; small kinetochore associated protein; Small kinetochore-associated protein; small kinetochore-associated protein, kinetochore-localized astrin-binding protein, TRAF4 associated factor 1; TRAF4 associated factor 1; TRAF4-associated factor 1
Gene Aliases: C15orf23; HSD11; KNSTRN; SKAP; TRAF4AF1
UniProt ID: (Human) Q9Y448
Entrez Gene ID: (Human) 90417