Immunogen sequence: ALAVIWSHEC VVCFFAGHTH DGGYSEDPFG VYHVNLEGVI ETAPDSQAFG TVHVYPDKMM LKGRGRVPDR IMNYKKERAF HC
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.
Ataxin-2 binding protein 1 has an RNP motif that is highly conserved among RNA-binding proteins. This protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the gene product of the SCA2 gene which causes familial neurodegenerative diseases. Ataxin-2 binding protein 1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been found but their full length nature has not been determined.
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Protein Aliases: ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; ADP-ribose/CDP-alcohol pyrophosphatase; ADPRibase-Mn; CDP-choline phosphohydrolase; Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Gene Aliases: ADPRM; C17orf48; MDS006; NBLA03831
UniProt ID: (Human) Q3LIE5
Entrez Gene ID: (Human) 56985