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C17orf96 Antibody (61754) in WB
C17orf96 antibody (pAb) tested by Western blot. Detection of C17orf96 by Western blot analysis. Lane 1: Mouse ES cell nuclear extract. Lane 2: Mouse ES cell nuclear extract from cells with a C17orf96 knockdown. Lane 3: Mouse ES cell nuclear extract from cells with C17orf96 overexpressed. All probed with C17orf96 antibody at a dilution of 1:1,000.
Product Details
61754
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This antibody was raised against a recombinant protein corresponding to amino acids 59-229 of mouse C17orf96.
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
70mM tris, pH 8, with 30% glycerol, 0.07mM EDTA, 31mM glycine, 105mM NaCl
Contains
0.035% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
Elongin BC and Polycomb repressive complex 2-associated protein (EPOP) also know as C17ORF96 is a scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex. It is required to fine tune the transcriptional status of polycomb group (PcG) target genes in embryonic stem cells (ESCs). C17ORF96 also plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression of PcG target genes. It acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. C17ORF96 also has interacts with USP7 and promotes deubiquitination of H2B at promoter sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Elongin BC and Polycomb repressive complex 2-associated protein; Embryonic stem cell-specific PRC2 subunit p48; ES cell-specific PRC2 subunit p48; uncharacterized protein C17orf96 homolog
Gene Aliases: AA409164; AI413509; AW539173; E13; Epop; esPRC2p48
UniProt ID: (Mouse) Q7TNS8
Entrez Gene ID: (Mouse) 103551
Performance Guarantee
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