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C19orf52 Antibody (PA5-100225) in ICC/IF
Immunofluorescent analysis of C19orf52 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and C19orf52 polyclonal antibody (Product # PA5-100225) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-100225
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TIMM29(Accession Q9BSF4), corresponding to amino acid residues H205-Q255.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2815755
Product Specific Information
Antibody detects endogenous levels of total C19orf52.
Target Information
TIMM29, also known as C19orf52, is identified as a novel subunit of the human TIM22 complex, which plays a critical role in the mitochondrial inner membrane. This protein is crucial for the stability of the TIM22 complex, which is responsible for the translocation of hydrophobic inner mitochondrial membrane proteins carrying internal targeting signals. TIMM29/C19orf52 is integrated into the mitochondrial inner membrane, exposing its C-terminus to the intermembrane space, and is vital for mitochondrial function and protein import pathways. This gene's importance is underscored by its involvement in processes related to mitochondrial integrity and its potential role in neurodegenerative disorders and viral interactions, such as those with the hepatitis B virus (HBV).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mitochondrial import inner membrane translocase subunit Tim29; TIM29; uncharacterized protein C19orf52 homolog
Gene Aliases: c19orf52; TIMM29
UniProt ID: (Mouse) Q8BGX2, (Human) Q9BSF4
Entrez Gene ID: (Mouse) 69773, (Human) 90580
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