Immunogen sequence: PVYQIQNRG MGTAAPAAMD PVVGQAKLLP PERMKHSIKL VDDQMNWCDS AIEYLLDQTD VLVVGVLGLQ GTGKSMVMSL LSANTPEEDQ RTYVFRAQSA EMKERGGNQT SGIDFFITQE RIVFLDTQPI LSPSILDHLI NNDRKLPPEY NLPHTYVEMQ SLQIAAFLFT VCHVVIVVQD WFTDLSLYRF LQTAEMVKPS TPSPSHESSS SSGSDEGTEY YPHLVFLQNK ARREDFCPRK LRQMHLMIDQ LMAHSHLRYK GTLSMLQCNV FPGLPPDFLD SEVNLFLVPF MDSEAESENP PRAGPGSSPL FSLLPGYRGH PSFQSLVSKL RSQVMSMARP QLSHTILTEK NWFHYAARIW DGVRKSSALA EYSRLLA (145-520 aa encoded by BC008869 )
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
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Protein Aliases: Nonsense-mediated mRNA decay factor SMG9; protein smg-9 homolog
Gene Aliases: C19orf61; F17127_1; HBMS; SMG9
UniProt ID: (Human) Q9H0W8
Entrez Gene ID: (Human) 56006